South Africa beat Australia by 32 runs in the second one-day international at the Wanderers Stadium in Johannesburg on 27 September, sealing an unassailable 2-0 lead in the three-match series.
Australia won the toss and chose to field, sending South Africa in to bat first. David Miller made the most of the conditions, striking a career-best 142 off 93 balls, with 12 fours and nine sixes.
South Africa finished on 365/9 from their 50 overs. Captain Temba Bavuma made 103, his first ODI century at his home venue.
Bavuma and Miller put on 156 for the fourth wicket off 135 balls, the stand that pushed South Africa's total beyond Australia's reach.
It was Miller's eighth ODI century, and his fourth specifically against Australia. The result also gave South Africa a sixth successive bilateral ODI series win over the Australians.
Australia were bowled out for 333 in reply, 32 runs short of the target. Mitchell Marsh and Travis Head gave the chase the platform it needed, putting on 130 for the first wicket in 17 overs before both fell for 84.
Australia's middle order could not build on that start. It is the second match in a row in which the top order has laid a foundation the rest of the batting has failed to use.
Jack Edwards, playing just his second ODI for Australia, took 5/67, the first List A five-wicket haul of his career.
Australia's bowling attack was further stretched when paceman Nathan Ellis left the field with a side strain after bowling only four overs.
The match was staged as South African cricket's Pink Day, raising awareness of breast cancer. Instead of their own names, players wore the names of cancer survivors on the backs of their shirts.
Miller wore the name of his mother, Jenny.
Australia also lost the first ODI, on 24 September, by 67 runs. Marsh and Head had put on 90 in the first 10 overs of that match, but the chase fell away against the spin of Keshav Maharaj and Bjorn Fortuin.
The dead-rubber third and final ODI is next.